The Stem Cell Niche & Cancer Microenvironment
2015 SYMPOSIUM
 
11/12/2015
1:00 pm - 1:30 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRegistration
1:30 pm - 1:45 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiWelcome
Joshua Breunig, Cedars-Sinai Medical Center
Leland Chung, Cedars-Sinai Medical Center
Clive Svendsen, Cedars-Sinai Medical Center
1:45 pm - 2:10 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiNIH Program Overview
Dinah Singer, Director, Division of Cancer Biology, National Cancer Institute
2:10 pm - 3:00 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiIntroduction and Opening Keynote: "The Dominance of the Microenvironment in Organ-Specificity and Malignant Progression"
Mina Bissell, Distinguished Scientist in the Lawrence Berkeley National Laboratory, UC Berkeley
Leland Chung, Cedars-Sinai Medical Center
3:00 pm - 3:15 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRefreshment Break
3:15 pm - 3:40 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiSession I: Genes and their Action in the Tumor Microenvironment
Chairs: William Nelson and Leland Chung

Prostate Cancer Epigenetics
William Nelson, Johns Hopkins University
3:40 pm - 4:05 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiGene Regulatory Interactions Controlling Neural Crest Stem Cell Formation
Marianne Bronner, California Institute of Technology
4:05 pm - 4:30 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiThe Function Role of Stroma and Exosomes in Pancreatic Cancer
Raghu Kalluri, MD Anderson
4:30 pm - 4:55 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiDiscussion Panel
4:55 pm - 5:10 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiPoster Teaser
5:10 pm - 7:00 pmHarvey Morse Auditorium, Rooms 1-3Poster Session I (even numbered), Reception and Networking
 
11/13/2015
8:30 am - 9:00 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiSession II: Stemness and Therapeutic Resistance
Chairs: Dean Tang and Neil Bhowmick

Breakfast
9:00 am - 9:25 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiTreatment-Induced Damage Responses in the Tumor Microenvironment: Targeting Master Regulators
Peter Nelson, Fred Hutchinson Cancer Research Center
9:25 am - 9:50 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiInsights into the Interaction between Tumor and Stroma from Novel Glioma Models
Joshua Breunig, Cedars-Sinai Medical Center
9:50 am - 10:15 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiA Multi-Cancer Gene Signature Associated with Stromal Activation
Sandra Orsulic, Cedars-Sinai Medical Center
10:15 am - 10:40 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRefreshment Break
10:40 am - 11:05 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiMicroenvironment Programmed Metastatic Prostate Cancer Stem Cell
Dean Tang, The University of Texas
11:05 am - 11:30 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiDiscussion Panel
11:30 am - 12:30 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiLunch
12:30 pm - 12:55 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiSession III: Tumor Progression and Microenvironment
Chairs: Xiaojiang Cui and Rumela Chakrabarti

Cell Fate Regulators in Mammary Gland Development and Breast Cancer
Rumela Chakrabarti, University of Pennsylvania
12:55 pm - 1:20 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRole of the Stroma in Prostate Cancer Initiation, Maintenance, and Metastasis
Massimo Loda, Harvard University
1:20 pm - 1:45 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiMesenchymal Stem Cells, the Bone Marrow Niche and Drug Resistance
Yves DeClerck, Childrens Hospital Los Angeles/University of Southern California
1:45 pm - 2:00 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRefreshment Break
2:00 pm - 2:25 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiCross-Talk between Endothelial and Tumor Cells in Cancer
Luisa Iruela-Arispa, University of California, Los Angeles
2:25 pm - 2:50 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiDiscussion Panel
2:50 pm - 3:15 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiSession IV: Immune Interactions in the Cancer Microenvironment
Chairs: Dolores DiVizio and Muller Fabbri

Role of Exosomic MicroRNAs in the Biology of the Tumor Microenvironment
Muller Fabbri, Childrens Hospital Los Angeles/University of Southern California
3:15 pm - 3:40 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiImpact of Macrophage Polarization on the Response to Chemotherapy and Radiation
Stephen Shiao, Cedars-Sinai Medical Center
3:40 pm - 4:05 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiMyelin Plasticity in Health and Disease
Michelle Monje, Stanford University
4:05 pm - 4:20 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiRefreshment Break
4:20 pm - 4:45 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiGenetic Control of Glioblastoma Stem Cell Self-Renewal
John Yu, Cedars-Sinai Medical Center
4:45 pm - 5:10 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiDiscussion Panel
 
11/14/2015
8:00 am - 8:20 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiSession V: Clinical Implications: From Bench to Bedside
Chairs: Clive Svendsen and Beth Karlan

Breakfast
8:30 am - 8:55 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiHematopoietic Stem Cell Gene Therapy
Donald Kohn, University of California, Los Angeles
8:55 am - 9:20 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiBeating Prostate Cancer and Other Malignancies by Chemo-Immunotherapy – The Importance of Immunosuppressive Plasmocytes
Michael Karin, University of California, San Diego
9:20 am - 9:45 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiClinical Microfluidics: Isolation of Circulating Tumor Cells and Microvesicles from Cancer Patients
Shannon Stott, Massachusetts General Hospital
9:45 am - 10:45 amHarvey Morse Auditorium, Rooms 1-3Poster Session II (odd numbered) and Refreshment Break
10:45 am - 11:10 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiAcute Leukemia: Genomic Abnormalities, Even Before the Disease Develops
Phillip Koeffler, Cedars-Sinai Medical Center
11:10 am - 11:35 amHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiDiscussion
11:35 am - 12:00 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiLunch
12:00 pm - 12:50 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiIntroduction and Closing Keynote: "The Hematopoietic Stem Cell Niche"
Sean Morrison, Director of the Children's Medical Center Research Institute, UT Southwestern
Clive Svendsen, Cedars-Sinai Medical Center
12:50 pm - 1:00 pmHarvey Morse Auditorium, Plaza Level, South Tower, Cedars-SinaiAnnouncements/Poster Winners
Joshua Breunig, Cedars-Sinai Medical Center
Leland Chung, Cedars-Sinai Medical Center
Clive Svendsen, Cedars-Sinai Medical Center