Title Associate Professor of Drug Discovery and Biomedical Sciences Company Medical University of South Carolina Bio Dr. Sherine Chan is an Associate Professor of Drug Discovery and Biomedical Sciences at the Medical University of South Carolina, in Charleston, SC. She is also the Co-Founder of two startup companies: Neuroene Therapeutics, based on compounds discovered for epilepsy and other difficult to treat neurological diseases, and Lydex Pharmaceuticals, which is developing treatments for Acute Myelogenous Leukemia.Dr. Chan graduated with a B.Sc. (Hons.) in Veterinary Biology in 1996 from Murdoch University, Australia, and a Ph.D. in Clinical Biochemistry from the University of Western Australia in 2002. Dr. Chan first developed her passion for mitochondrial diseases under the tutelage of Dr. James Cummins at Murdoch University, investigating the roles of mitochondrial DNA mutagenesis in male infertility. Later, she joined Dr. William Copeland’s laboratory for postdoctoral training at the National Institute of Environmental Health Sciences (National Institutes of Health), in Research Triangle Park, NC, where she focused on mitochondrial diseases using in vitro biochemistry, studies of mitochondrial disease patient cells, and in vivo mouse models of mitochondrial dysfunction. The long-term goal of her laboratory at the Medical University of South Carolina is to manipulate the mechanisms required to maintain mitochondrial homeostasis to prevent or treat mitochondrial dysfunction. Her team has developed new zebrafish models of mitochondrial dysfunction that recapitulate human disease, which are now being used for studying disease progression, for drug discovery and for toxicology studies