Quantitative Modeling of Gene Expression by Using DNA Shape and Accessibility DataOctober 19, 2016 Track: General Complex diseases have been linked to altered gene expression due to abnormal DNA sequences. However, the precise relationship is not fully understood. We develop a quantitative model to predict gene expression from DNA sequence, using accessibility and DNA shape data. Results show models incorporating heterogeneous data perform better than sequence-only model, and better elucidate gene regulation. Speaker(s)
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