ABSTRACT
Retrospective observational study of acute stroke thrombolysis at
a secondary healthcare centre in Queensland, Australia
Dibia U 1, 2, Saleem J 1, Alchin B 3
1 Department of Internal Medicine, Caboolture Hospital, Caboolture,
Queensland, Australia. 4510
2 University of Queensland, St Lucia, Queensland, Australia. 4072
3 Caboolture-Kilcoy Hospitals Innovation and Research Program,
Caboolture, Queensland, Australia. 4510.
Background: Achieving a door to needle time of less than 60 minutes may lead to
inadvertent thrombolysis of stroke mimics.
Aims/Objectives:
To provide descriptive data on stroke thrombolysis patients at Caboolture
hospital so as to aid better patient selection for the procedure.
Methods:
A retrospective chart review of all patients with acute ischaemic stroke seen
between October 1 2013 and June 30 2015 at the Caboolture hospital.
Results:
A total of 26 patients (Male 13, Female 13) received stroke thrombolysis. The
mean age for all patients was of 76 years.
The average door to needle time was 92minutes (range 30-213
minutes). 24 hour post-thrombolysis
computer tomography (CT) imaging confirmed ischaemic stroke in 13(52%) of the
thrombolysis patients, whilst 12(48%) did not have ischaemic stroke. Of the 13
confirmed stroke patients, recovery within 24 hours was seen in 4 patients
(31%), whilst 9(75%) of the unconfirmed strokes had recovery in the same
timeframe. 1(7.7%) patient had symptomatic intracranial haemorrhage in the
confirmed stroke group whilst 2(16.7%) in the unconfirmed group had
haemorrhage. There were 4 deaths recorded in the confirmed stroke group, whilst
only 1 death occurred in those with unproven stroke.
Conclusion:
Based on delayed CT imaging, almost half of our patients did not have an
ischaemic stroke. Better patient selection prior to thrombolysis and better
imaging modalities will prevent potential patient harm and obvious waste of
resources.