2017 CSS Conference
 
Friday CSS-SRS New Frontiers Satellite Meeting Program - New Frontiers in Sleep Mechanisms and Functions
Friday, April 28, 2017
7:00 am - 7:00 pmRegistration Open
8:00 am - 4:00 pmCSS-SRS New Frontiers Satellite Meeting - New Frontiers in Sleep Mechanisms and Functions

This 1-day meeting will provide a comprehensive and state-of-the-art update of the basic mechanisms and functions underlying sleep in both health and disease. It will feature scientific talks and discussions that focus on: 

  1. How the brain functions to generate and control sleep and wakefulness; 
  2. How changes in brain activity during sleep impacts its function during waking; 
  3. How the genome impacts the control of brain function during sleep.
Sponsored by 

See CSS-SRS New Frontiers Satellite Program - Friday for the detailed agenda.
8:00 am - 9:45 amSession I: Connectomics: Circuit Control of Sleep-wake Behaviors

This session will examine how brain circuits communicate to produce normal sleep and how sleep can impact the circuits that enable learning and memory.

Learning objectives:
  1. To understand how the CNS controls arousal
  2. To understand CNS control of both slow-wave sleep and REM sleep
  3. To understand how sleep impacts learning and memory
8:00 am - 8:30 amIdentification of Novel Circuits Controlling Arousal
Jimmy J. Fraigne PhD, Research Associate, University of Toronto
Synchronizing arousal and motor activity is required for performing purposeful behaviors like locomotion and even for maintaining simple body posture. Failure of this coupling leads to dissociative states such as cataplexy (i.e. sudden muscle paralysis while awake) or abnormal movement in sleep (i.e., sleep walking or REM sleep behavior disorder). Using optogenetics, we identified a novel dopamine arousal circuit in the hypothalamus that functions to couple arousal and motor activity.
8:30 am - 9:00 amRole of REM Sleep in Memory Consolidation
Sylvain Williams PhD, McGill University
9:00 am - 9:30 amThe Hypothalamic and Thalamic Connectome and its Role in Sleep Control
Carolina Gutierrez Herrera PhD, Research Associate, University of Bern
9:30 am - 9:45 amSession I: General Discussion
9:45 am - 10:00 amHealth Break & Exhibits Open
10:00 am - 11:00 amKeynote: Integrating new circuits and laying out remaining big questions
Yang Dan PhD, Howard Hughes Medical Institute Investigator and Professor of Neurobiology, University of California, Berkeley
In this presentation I will summarize our recent effort to understand the neuronal circuits controlling REM and non-REM sleep. We use a variety of modern techniques, including optogenetics, imaging, and virus-assisted circuit tracing. I will illustrate how these approaches can lead to new insights into the brain mechanisms regulating sleep.

Learning Objectives:
  1. To identify neurons in the brain that are important for controlling sleep
  2. To map the connections in the sleep control network
  3. To understand the mechanisms underlying sleep pressure
11:00 am - 12:45 pmSession II: Synaptomics: Building or Breaking Synapses in Sleep?

This session examines how sleep impacts cells and their communication pathways, and it examines how sleep loss can impair the ability of cells to communicate effectively in both health and disease.

Learning objectives:

  1. To understand how sleep impacts the ability of brain cells to communicate effectively
  2. To understand how different types of sleep impact cell-to-cell communication processes
  3. To understand how sleep loss impairs cell synapses

11:00 am - 11:30 amThe Role of Sleep in Neuronal Activity Homeostasis
Keith Hengen PhD, Assistant Professor, Department of Biology, Washington University in St. Louis
Homeostatic plasticity allows neural networks to achieve a paradoxical balance of rapid modifiability and long term stability. By studying homeostatic processes in freely behaving animals, we revealed a set of arousal state-dependent rules. These data suggest that temporal segregation of plasticity mechanisms subserves state-specific functions such as homeostasis and memory consolidation.
11:30 am - 12:00 pmSleep Homeostasis and Synaptic Plasticity Elements
Valerie Mongrain PhD, Research Professor, Université de Montréal
Our work has revealed that different cell adhesion proteins shaping synaptic functioning and plasticity have roles in the regulation of sleep state quantity and quality. The presentation will feature results indicating that mice with mutations in cell adhesion elements have several alterations in electroencephalographic activity, including in sleep slow waves, and that wakefulness and sleep impacts the expression of these elements. The transcriptional machinery and intracellular mechanisms likely impacting cell adhesion protein expression during sleep deprivation will also be discussed.
12:00 pm - 12:30 pmRole of Sleep in Synapse and Memory Formation
Guang Yang PhD, Assistant Professor, NYU School of Medecine
How sleep helps learning and memory remains unknown. Using in vivo two-photon imaging, we longitudinally observed how postsynaptic dendritic spines in the mouse cortex are formed and maintained during sleep and after learning. Our recent findings indicate that sleep contributes to learning and memory storage by promoting learning-dependent synapse formation and maintenance on selected branches of pyramidal neurons.
12:30 pm - 12:45 pmSession II: General Discussion
12:45 pm - 1:45 pmTrainee-Mentor Lunch
1:45 pm - 2:45 pmKeynote - Sleep’s Influence on Learning and Memory
Bruce McNaughton PhD, Professor, University of Lethbridge, AB
Damage to the hippocampal formation (HC) results in severe deficits in the acquisition of two types of memory, which are categorized as “episodic memory” and “semantic memory”. The former refers to the internal records of autobiographical experience that can be verbally described in terms of specific events and their spatiotemporal contexts, whereas the latter refers to generalized knowledge; our internal model of the world and its statistical and categorical structure and temporal dynamics, from which we are able to make predictions about the properties of objects and situations, and the outcomes of events and our own actions. I am concerned with the neural interactions between and within HC and NC that may underlie the extraction of semantic knowledge from episodic memory. Substantial evidence indicates that this process occurs primarily during slow-wave sleep, which will be the main theme of the lecture.

At the end of this talk, participants should:

  1. Understand and describe the basic hierarchical/ modular structure of the cortical memory system
  2. Understand and explain why hippocampal damage leads to impaired episodic and semantic learning
  3. Be able to describe the process of memory trace reactivation during sleep from the cellular/neurophysiological perspective

2:45 pm - 4:30 pmSession III: Genomics: Mechanisms of Sleep Regulation

This session is aimed at examining how genes impact sleep and how sleep can impact gene expression.  This session focuses on sleep in humans, mice and flies and looks for commonality in sleep mechanisms between species

Learning objectives:

  1. To understand how different genes impact sleep and wakefulness
  2. To understand and identify which genes are impaired in candidate sleep disorders
  3. To understand if genes expression levels can impair sleep amounts

 

2:45 pm - 3:15 pmThe Genetics of Fly Sleep
Susan T. Harbison PhD, Earl Stadtman Tenure-Track Investigator, National Heart Lung and Blood Institute
One intriguing observation about sleep is that some individuals need to sleep longer than others. The basis for this need can be revealed through the identification of genetic factors contributing to individual differences. This presentation will discuss how artificial selection coupled with whole-genome DNA sequence data can be used to localize genes affecting variation in night sleep duration in Drosophila melanogaster. Extreme (9.97 hours) divergences in night sleep duration are traceable to changes in the allele frequency of genomic variants over time.
3:15 pm - 3:45 pmMechanisms of Sleep Control in Worms
David M. Raizen MD, PhD, DABSM, Associate Professor of Neurology, University of Pennsylvania
Dr. Raizen will present a neural and neurochemical basis of sleep during sickness. The mechanism was elucidated in his and other labs using invertebrate animal models.
3:45 pm - 4:15 pmCircuits Mediating Sleep Homeostasis
Sha Liu Ph.D., Postdoctoral Fellow, Johns Hopkins University School of Medicine
Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic drive is generated and subsequently persists is unclear. Recently, from a neural circuit screen in Drosophila, we identified the first neural circuit whose brief activation induces homeostatic sleep drive even in fully rested animals, a phenotype never previously observed in any organism. In addition, we demonstrated that neural plasticity of this circuit underlies generation and persistence of sleep drive. This paradigm-shifting mechanism provides an explanation for the gradual build-up and dissipation of sleep drive, as well as a new conceptual framework for future investigations into the homeostatic regulation of sleep.
4:15 pm - 4:30 pmSession III: General Discussion
4:30 pm - 6:00 pmAnnual General Meeting (AGM) of the Canadian Sleep Society (CSS)
Annual General Meeting (AGM) of the Canadian Sleep Society (CSS).
All current member of the CSS are invited to attend the AGM. Don't miss important updates on society finances, reports from board members, and plans for the future. This is your chance to have a say in activities and initiatives of the society.
6:30 pm - 8:00 pmWelcome Reception
An opportunity to enjoy a drink and network. Includes a traditional White Hat Ceremony. 

All attendees and exhibitors are invited to this reception hosted in the Foyer and Exhibit Hall for an opportunity to enjoy a drink and network. The White Hat Ceremony is a long-standing tradition in Calgary, a symbol of the Western hospitality and good cheer we like to share with visiting guests. The white Smithbilt hat has been bestowed on numerous celebrities and dignitaries on their visits to our city since the 1950s, when Calgary's Mayor, Don MacKay, started the tradition.

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